Tursun Research Group
Gene Regulation and Cell Fate Decision

Publications

 

The C. elegans pseudogene sspt-16 (F55A3.7) is required to safeguard germ cells against reprogramming

Andreas Ofenbauer, Clara Maria Kraus, Baris Tursun.

MicroPubl Biol. 2021 May 18;2021. doi: 10.17912/micropub.biology.000392. PMID: 34017942

 


SUMOylation of the chromodomain factor MRG-1 in C. elegans affects chromatin-regulatory dynamics

Gülkiz Baytek, Alexander Blume, Funda Gerceker Demirel, Selman Bulut, Philipp Mertins, Baris Tursun.

bioRxiv 2021, 2021.02.14.431134; doi: https://doi.org/10.1101/2021.02.14.431134

 

The CONJUDOR pipeline for simultaneous knockdown of multiple genes identifies RBBP-5 as a germ cell reprogramming barrier in C. elegans

Marlon Kazmierczak, Calota Farre i Diaz, Andreas Ofenbauer, Sergej Herzog, Baris Tursun.

Nucleic Acids Research 2021, https://doi.org/10.1093/nar/gkaa1171


Conversion of germ cell to somatic cell types in C. elegans

Nida ul Fatima, Baris Tursun.

Journal of Developmental Biology 2020, 8, 24; https://doi:10.3390/jdb8040024


Epigenetic Chaperoning of Aging   

Stefanie Müthel, Baris Tursun.

Aging 2020, https://doi.org/10.18632/aging.102808


Proteomic and Transcriptomic Changes in Hibernating Grizzly Bears Reveal Metabolic and Signaling Pathways that Protect against Muscle Atrophy

D.A. Mugahid, T.G. Sengül, X. You, L. Steil, N. Gergmann, M.H. Radke, A. Ofenbauer, M. Gesell-Salazar, A. Balogh, Stefan Kempa, Baris Tursun, T. Robbins, L. Nelson, M. Gotthardt.

Scientific Reports 2019, Dez 9; doi:10.1038/s41598-019-56007-8

The conserved histone chaperone LIN-53 is required for normal lifespan and maintenance of muscle integrity in Caenorhabditis elegans.

Stefanie Müthel, Bora Uyar, Mei He, Anne Krause, Burcu Vitrinel, Selman Bulut, Djordje Vasiljevic, Iris Marchal, Altuna Akalin, Stefan Kempa, Baris Tursun.

Aging Cell 2019, Aug 9:e13012. doi: 10.1111/acel.13012


CRISPR-activation-based screen reveals neuronal fate promotion by Polycomb Repressive Complex 2 during direct reprogramming.

Tim Wolfram, Baris Tursun.

Stem Cell Investigation 2019, doi: 10.21037/sci.2019.08.04


Strategies for in vivo Reprogramming

Andreas Ofenbauer, Baris Tursun.

Current Opinion in Cell Biology 2019, Elsevier 10.1016/j.ceb.2019.06.002 


HOT or not: examining the basis of high-occupancy target regions.

Wreczycka K, Franke V, Uyar B, Wurmus R, Bulut S, Tursun B, Akalin A.

Nucleic Acids Res. 2019 Jun 20;47(11):5735-5745. doi: 10.1093/nar/gkz460.

 

C. elegans and Systems Biology - its's 'Systems' all the way down!

Denis Dupuy and Baris Tursun.

Current Opinion in Systems Biology, 2019, Elsevier

https://doi.org/10.1016/j.coisb.2019.02.003

 

MRG-1/MRG15 is a Barrier for Germ Cell to Neuron Reprogramming in C. elegans

Martina Hajduskova*, Gülkiz Baytek*, Ena Kolundzic*, Alexander Gosdschan, Marlon Kazmierczak, Andreas Ofenbauer, Maria Lena Beato desl Rosal, Sergej Herzog, Nida ul Fatima, Philipp Mertins, Stefanie Seelk-Müthel, Baris Tursun.

Genetics 2019, early online Nov. 2018, doi.org/10.1534/genetics.118.301674.

 

Determinants of Transcription Initiation Directionality in Metazoans

Mahmoud M. Ibrahim, Aslihan Karabacak, Alexander Glahs, Ena Kolundzic, Antje Hirsekorn, Alexa Carda, Baris Tursun, Robert Zinzen, Scott Allen Lacadie, Uwe Ohler

Nature Communications 2018 Oct 26;9(1):4472. doi: 10.1038/s41467-018-06962-z.

 

Transdifferentiation: do transition states lie on the path of development?

Anna Reid, Baris Tursun.

Current Opinion in Systems Biology 2018, Elsevier

https://doi.org/10.1016/j.coisb.2018.07.004

 

FACT sets a barrier for cell fate reprogramming in C. elegans and Human cells

Ena Kolundzic, Andreas Ofenbauer, Selman Bulut, Bora Uyar, Anne Sommermeier, Stefanie Seelk, Mei He, Gülkiz Baytek, Antje Hirsekorn, Dubra Vucicevic, Altuna Akalin, Sebastian Diecke, Scott Allen Lacadie, Baris Tursun.

Developmental Cell 2018, https://doi.org/10.1016/j.devcel.2018.07.006


FACTs behind control of cell fate

Editor's Choice highlight of Kolundzic et al. 2018 DevCell

Science 2018, Aug. Vol. 316 Vol. 361, Issue 6405,


The UNC-8 /UNC-84 LINC members are required for body wall muscle nuclei positioning in C. elegans

Andreas Ofenbauer, Baris Tursun. 

Matters Select 2018, DOI: 10.19185/matters.201805000009


Application of RNAi and heat-shock-induced transcription factor expression to reprogram germ cells to neurons in C. elegans.

Ena Kolundžić, Stefanie Seelk, Baris Tursun. 

JoVE 2018, e56889, DOI:10.3791/56889.


PcG Proteins in Caenorhabditis elegans

Baris Tursun

Elsevier Academic Press 2017; ISBN: 978-0-12809737-3; doi.org/10.1016/B978-0-12-809737-3.00012-X


FACT sets a barrier for cell fate reprogramming in C. elegans and Human

Ena Kolundzic, Andreas Ofenbauer, Bora Uyar, Anne Sommermeier, Stefanie Seelk, Mei He, Gülkiz Baytek, Altuna Akalin, Sebastian Diecke, Scott Allen Lacadie, Baris Tursun.

bioRxiv 2017, doi: https://doi.org/10.1101/18511.

recommended by F1000: DOI: 10.3410/f.731255581.793537136.  


Neuronal Inhibition Of The Autophagy Nucleation Complex Extends Lifespan In Post-Reproductive C. elegans.

Thomas Wilhelm, Jonathan Byrne, Rebeca Medina, Ena Kolundžić, Johannes Geisinger, Martina Hajduskova, Baris Tursun and Holger Richly. 

Genes and Development 2017, September 7, doi: 10.1101/gad.301648.117.


Increasing Notch signaling antagonizes PRC2-mediated silencing to promote reprograming of germ cells into neurons.

Seelk S, Adrian-Kalchhauser I, Hargitai B, Hajduskova M, Gutnik S, Tursun B# and Ciosk R#.

Elife 2016 Sep 7;5. pii: e15477. doi: 10.7554/eLife.15477. PMID: 27602485

#B. Tursun is co-corresponding, B. Tursun is submitting author, S. Seelk is PhD student in Tursun lab


A tissue-specific protein purification approach in Caenorhabditis elegans identifies novel interaction partners of DLG-1/Discs large.

Waaijers S, Muñoz J, Berends C, Ramalho JJ, Goerdayal SS, Low TY, Zoumaro-Djayoon AD, Hoffmann M, Koorman T, Tas RP, Harterink M, Seelk S, Kerver J, Hoogenraad CC, Bossinger O, Tursun B#, van den Heuvel S, Heck AJ, Boxem M#.

BMC Biol. 2016 Aug 9;14:66. doi: 10.1186/s12915-016-0286-x. PMID: 27506200

#B. Tursun is co-corresponding


Two distinct types of neuronal asymmetries are controlled by the Caenorhabditis elegans zinc finger transcription factor die-1.

Cochella L*, Tursun B*, Hsieh YW, Galindo S, Johnston RJ, Chuang CF, Hobert O.

Genes Dev. 2014 Jan 1;28(1):34-43. doi: 10.1101/gad.233643.113. Epub 2013 Dec 20.

PMID: 24361693 *co-first


Removal of Polycomb repressive complex 2 makes C. elegans germ cells susceptible to direct conversion into specific somatic cell types.

Patel T*, Tursun B*, Rahe DP, Hobert O.

Cell Reports 2012 Nov 29;2(5):1178-86. doi: 10.1016/j.celrep.2012.09.020. Epub 2012 Oct 25.

PMID: 23103163 *co-first


Cellular reprogramming processes in Drosophila and C. elegans.

Tursun B.

Curr Opin Genet Dev. 2012 Oct;22(5):475-84. doi: 10.1016/j.gde.2012.09.005. Epub 2012 Oct 11. Review.

PMID: 23063246


Direct conversion of C. elegans germ cells into specific neuron types.

Tursun B#, Patel T, Kratsios P, Hobert O. (#co-corresponding)

Science 2011 Jan 21;331(6015):304-8. doi: 10.1126/science.1199082. PMID: 21148348

#B. Tursun is co-corresponding

       Featured / Commented by:

The Groucho ortholog UNC-37 interacts with the short Groucho-like protein LSY-22 to control developmental decisions in C. elegans.

Flowers EB, Poole RJ, Tursun B, Bashllari E, Pe'er I, Hobert O.

Development 2010 Jun;137(11):1799-805. doi: 10.1242/dev.046219. Epub 2010 Apr 28.

PMID: 20431118


Neuron-type specific regulation of a 3'UTR through redundant and combinatorially acting cis-regulatory elements.

Didiano D, Cochella L, Tursun B, Hobert O.

RNA 2010 Feb;16(2):349-63. doi: 10.1261/rna.1931510. Epub 2009 Dec 29.

PMID: 20040592


The C. elegans Tailless/TLX transcription factor nhr-67 controls neuronal identity and left/right asymmetric fate diversification.

Sarin S, Antonio C, Tursun B, Hobert O.

Development 2009 Sep;136(17):2933-44. doi: 10.1242/dev.040204. Epub 2009 Jul 29.

PMID: 19641012


A toolkit and robust pipeline for the generation of fosmid-based reporter genes in C. elegans.

Tursun B*#, Cochella L*, Carrera I, Hobert O.#

PLoS One 2009;4(3):e4625. doi: 10.1371/journal.pone.0004625. PMID: 19259264

#B. Tursun is co-corresponding


Regulation of estrogen-dependent transcription by the LIM cofactors CLIM and RLIM in breast cancer.

Johnsen SA, Güngör C, Prenzel T, Riethdorf S, Riethdorf L, Taniguchi-Ishigaki N, Rau T, Tursun B, Furlow JD, Sauter G, Scheffner M, Pantel K, Gannon F, Bach I.

Cancer Res. 2009 Jan 1;69(1):128-36. doi: 10.1158/0008-5472.CAN-08-1630.

PMID: 19117995


Proteasomal selection of multiprotein complexes recruited by LIM homeodomain transcription factors.

Güngör C, Taniguchi-Ishigaki N, Ma H, Drung A, Tursun B, Ostendorff HP, Bossenz M, Becker CG, Becker T, Bach I.

PNAS 2007 Sep 18;104(38):15000-5. Epub 2007 Sep 11. Erratum in: Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):17239. PMID: 17848518


Dynamic expression of LIM cofactors in the developing mouse neural tube.

Ostendorff HP*, Tursun B*, Cornils K, Schlüter A, Drung A, Güngör C, Bach I.

Dev Dyn. 2006 Mar;235(3):786-91. PMID: 16395690 (*co-first)


The ubiquitin ligase Rnf6 regulates local LIM kinase 1 levels in axonal growth cones.

Tursun B, Schlüter A, Peters MA, Viehweger B, Ostendorff HP, Soosairajah J, Drung A, Bossenz M, Johnsen SA, Schweizer M, Bernard O, Bach I.

Genes Dev. 2005 Oct 1;19(19):2307-19. PMID: 16204183


Mitochondrial signal peptidases of yeast: the rhomboid peptidase Pcp1 and its substrate cytochrome C peroxidase.

Michaelis G, Esser K, Tursun B, Stohn JP, Hanson S, Pratje E.

Gene 2005 Jul 18;354:58-63. PMID: 15979251


Comparing protein stabilities during zebrafish embryogenesis.

Becker T, Bossenz M, Tursun B, Schlüter A, Peters MA, Becker CG, Ostendorff HP, Bach I.

Methods Cell Sci. 2003;25(1-2):85-9. PMID: 14739592


A novel two-step mechanism for removal of a mitochondrial signal sequence involves the mAAA complex and the putative rhomboid protease Pcp1.

Esser K, Tursun B, Ingenhoven M, Michaelis G, Pratje E.

J Mol Biol. 2002 Nov 8;323(5):835-43. PMID: 12417197


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